NFLregular season 2025

SF

San Francisco 49ers

@

LAR

Los Angeles Rams

20
-
23
Los Angeles Rams win by 3

Confidence Levels

Win Confidence62%

Confidence in predicting the winner

Spread Confidence54%

Confidence in beating the spread

Total Confidence57%

Confidence in the over/under prediction

Predicted Total Points43

AI Analysis

Los Angeles pairs a cleaner turnover profile with superior yards per play and a more productive passing attack, while its defense is generating far more pressure and takeaways. With Purdy and multiple SF receivers banged up and the 49ers’ run game at just 3.32 YPA, the Rams’ home field and red-zone edge tilt a close, low-40s game their way.

Win confidence (0.62) reflects clear but not overwhelming edges for LAR in efficiency and turnover differential, tempered by SF’s strong third-down offense and recent H2H success. Spread confidence (0.54) is modest because both teams trend toward one-score finishes. Total confidence (0.57) is mid: stable indoor conditions and high red-zone rates suggest a low-to-mid 40s total, but turnover volatility could swing scoring.

Key Factors

  • Offensive efficiency edge: Rams 6.34 yards/play vs 49ers 5.66; Rams passing 8.13 YPA (7.38 net) vs SF 7.51 YPA (7.04 net).
  • Turnover profile favors LAR: +3 differential (4 giveaways) vs SF -5 (8 giveaways).
  • Havoc differential: Rams defense 14 sacks and 7 takeaways through 4 games vs 49ers 5 sacks and 3 takeaways.
  • Brock Purdy (toe) questionable on a short week; WRs Jauan Jennings (ankle/ribs) and Ricky Pearsall (knee) also questionable—potentially limiting SF’s passing depth.
  • Rams injuries (TE Tyler Higbee—hip; RT Rob Havenstein—questionable) are mitigated by SF’s modest sack output (5), reducing pass-protection risk.
  • Recent form: last-3 scoring—Rams 24.3 PF/20.3 PA vs 49ers 19.7 PF/16.3 PA—points to a slight LAR edge.
  • Both teams finish drives well (RZ TD: LAR 81.25%, SF 78.57%); indoor conditions remove weather variance, favoring the more efficient passing team.
  • Counterbalance: SF converts 48.1% on third down and won the last two meetings (12-6, 27-24), implying a one-score script.

Current Betting Lines

Line Movement

Spread:0.0
Total:+0.5
ML:-7
SportsbookSpreadTotalMoneylineUpdated
Bally BetSF +3(-112)47(-112/-109)
SF +133
LAR -162
4d ago
BetOnline.agSF +3(-105)47(-110/-110)
SF
LAR
4d ago
betPARXSF +3(-112)47(-112/-109)
SF +133
LAR -162
4d ago
BetRiversSF +3(-114)47(-114/-112)
SF +123
LAR -162
4d ago
BetUSSF +3(-105)47(-110/-110)
SF
LAR
4d ago
BovadaSF +3(-115)46.5(-110/-110)
SF +135
LAR -160
4d ago
DraftKingsSF +3(-110)46.5(-115/-105)
SF +130
LAR -155
4d ago
FanDuelSF +3(-110)47.5(-105/-115)
SF +134
LAR -158
4d ago
FliffSF +2.5(105)47.5(-105/-120)
SF +130
LAR -165
4d ago
LowVig.agSF +3(100)47(-107/-107)
SF
LAR
4d ago
MyBookie.agSF +3(-110)46.5(-110/-110)
SF +128
LAR -165
4d ago

Game Information

Venue

SoFi Stadium
Inglewood, CA
Indoor Stadium